Volume 7 Issue 1
Jun.  2023
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Xue Rui, Hongjun Gao, Yu Zhang, Jiling Xu, Chengtao He, Qiang Fu. RHD haplotype analysis of a D negative cohort[J]. Blood&Genomics, 2023, 7(1): 43-47. doi: 10.46701/BG.2023012022033
Citation: Xue Rui, Hongjun Gao, Yu Zhang, Jiling Xu, Chengtao He, Qiang Fu. RHD haplotype analysis of a D negative cohort[J]. Blood&Genomics, 2023, 7(1): 43-47. doi: 10.46701/BG.2023012022033

RHD haplotype analysis of a D negative cohort

doi: 10.46701/BG.2023012022033
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  • Corresponding author: Chengtao He, Red Cell Reference Laboratory, Nanjing Red Cross Blood Center, Nanjing, Jiangsu 210003, China. E-mail: hechengtao413@126.com; Qiang Fu, Department of Blood Management, Nanjing Red Cross Blood Center, Nanjing, Jiangsu 210003, China. E-mail: fuqiangnj@hotmail.com
  • Received Date: 2022-11-14
  • Rev Recd Date: 2023-04-17
  • Accepted Date: 2023-05-26
  • Available Online: 2023-07-05
  • Publish Date: 2023-06-30
  • This study aimed to explore the distribution of the variant RHD genotypes in Jiangsu, China. A total of 108541 blood donor samples and 17 family members were tested from 2020 to 2021. A total of 121 RHD variants were found in 414 D negative samples and their families, including seven weak D, four partial, and three Del alleles. RHD*15 and RHD*DVI.3 were the prevalent D variant alleles in Jiangsu Province. Heterozygous alleles were identified (c.730G>C, c.1227G>A), and a case of unique intronic mutation was detected (c.802-41_802-38delCTCT). This study suggests that the frequency of RHD variants is crucial for establishing specific RHD genotyping strategies and can be applied in larger-scale routine tests for blood donors.


  • These authors contributed equally to this work.
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