Volume 6 Issue 2
Dec.  2022
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Jikai He, Jiaqi Jia, Wenhao Qu, Lizhou Jia, Wei Zhao. The function and regulatory mechanism of B cells in tumor immunity[J]. Blood&Genomics, 2022, 6(2): 103-113. doi: 10.46701/BG.2022022022031
Citation: Jikai He, Jiaqi Jia, Wenhao Qu, Lizhou Jia, Wei Zhao. The function and regulatory mechanism of B cells in tumor immunity[J]. Blood&Genomics, 2022, 6(2): 103-113. doi: 10.46701/BG.2022022022031

The function and regulatory mechanism of B cells in tumor immunity

doi: 10.46701/BG.2022022022031
Funds:  Review Article
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  • Corresponding author: Wei Zhao, Department of Pathology, Nanjing First Hospital, Nanjing Medical University, No. 68 Changle Road, Nanjing, Jiangsu 210006, China. E-mail: zhaowei_njmu@163.com
  • Received Date: 2022-11-04
  • Rev Recd Date: 2022-11-28
  • Accepted Date: 2022-11-29
  • Available Online: 2023-07-17
  • Publish Date: 2022-12-30
  • B cells are important components of the human immune system, and play a role in the process of specific immunity. In recent years, research on B cells and tumor immunity has made rapid progress. Studies have shown that different types of B cells play different roles in the tumor microenvironment (TME) through a variety of mechanisms. Tumor-infiltrating B cells (TIBs) in the TME play an anti-tumor role by secreting antibodies and presenting antigens, while regulatory B cells (Bregs) inhibit the immune response by secreting a variety of cytokines, thereby promoting tumor immune escape. This review introduces the roles and mechanisms of different subtypes of B cells in different types of tumors.


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