Volume 5 Issue 1
Jun.  2021
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Xiaowei Sun, Wenyue Zheng, Rui Hua, Yujie Liu, Li Wang, Yun-Gi Kim, Xinqi Liu, Hitomi Mimuro, Zhongyang Shen, Lian Li, Sei Yoshida. Macropinocytosis and SARS-CoV-2 cell entry[J]. Blood&Genomics, 2021, 5(1): 1-12. doi: 10.46701/BG.2021012021110
Citation: Xiaowei Sun, Wenyue Zheng, Rui Hua, Yujie Liu, Li Wang, Yun-Gi Kim, Xinqi Liu, Hitomi Mimuro, Zhongyang Shen, Lian Li, Sei Yoshida. Macropinocytosis and SARS-CoV-2 cell entry[J]. Blood&Genomics, 2021, 5(1): 1-12. doi: 10.46701/BG.2021012021110

Macropinocytosis and SARS-CoV-2 cell entry

doi: 10.46701/BG.2021012021110
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  • Corresponding author: Zhongyang Shen, Organ Transplant Department, Tianjin First Central Hospital, Tianjin 300192, China. E-mail: zhongyangshen@vip.sina.com; Lian Li, State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Frontiers Science Center for Cell Responses, Nankai University, No. 94 Weijin Road, Tianjin 300071, China. E-mail: lilian523@nankai.edu.cn; Sei Yoshida, State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Frontiers Science Center for Cell Responses, Nankai University, No. 94, Weijin Road, Tianjin 300071, China. E-mail: seiyoshi@nankai.edu.cn
  • Received Date: 2021-04-05
  • Rev Recd Date: 2021-04-25
  • Accepted Date: 2021-05-08
  • Publish Date: 2021-06-01
  • Macropinocytosis is a type of large-scale endocytosis that is triggered by the interaction of receptor proteins and ligands, such as growth factors, cytokines, chemokines, and lipopolysaccharide (LPS). Macropinocytosis ingests the extracellular fluid solutes and conveys them into the lysosome in the context of cell growth and differentiation. Aside from its physiological functions, macropinocytosis has been observed in viral infections. While the infectious mechanism of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still unknown, recent studies suggest the involvement of macropinocytosis in its cell entry. In this review, we discuss the roles of endocytosis in SARS-CoV/SARS-CoV-2 cell entries and propose a hypothetical role of macropinocytosis in SARS-CoV-2 cell entry.


  • These authors contributed equally to this work.
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