Volume 5 Issue 1
Jun.  2021
Turn off MathJax
Article Contents
Jianjun Wu, Bin Jiang, Renxue Xiang, Ronghui Shi, Changsheng He, Kang Yang, Xin Cui, Shuming Zhao. A massive dose of allogeneic platelet gel for wound hemostatic therapy on patients with giant thoracic aortic aneurysm: report of 2 cases[J]. Blood&Genomics, 2021, 5(1): 57-62. doi: 10.46701/BG.2021012021105
Citation: Jianjun Wu, Bin Jiang, Renxue Xiang, Ronghui Shi, Changsheng He, Kang Yang, Xin Cui, Shuming Zhao. A massive dose of allogeneic platelet gel for wound hemostatic therapy on patients with giant thoracic aortic aneurysm: report of 2 cases[J]. Blood&Genomics, 2021, 5(1): 57-62. doi: 10.46701/BG.2021012021105

A massive dose of allogeneic platelet gel for wound hemostatic therapy on patients with giant thoracic aortic aneurysm: report of 2 cases

doi: 10.46701/BG.2021012021105
More Information
  • Corresponding author: Shuming Zhao, Department of Blood Transfusion, GuiQian International General Hospital, No 1, Dongfeng Street, Wudang District, Guiyang, Guizhou 550018, China. E-mail: shumingzhao123@qq.com
  • Received Date: 2021-02-25
  • Accepted Date: 2021-04-22
  • Rev Recd Date: 2021-03-24
  • Publish Date: 2021-06-01
  • Autologous platelet-rich plasma (PRP) or platelet gel (PG) has been widely used in clinical treatment. Allogeneic PRP or PG may also become a safe and effective alternative method. In this study, two cases with giant thoracic aortic aneurysm were reported where massive doses of allogeneic PG were used to spray the thoracic aortic aneurysm wall suture wrapped in artificial blood vessels, tumors blood vessel wall anastomotic site, and incision site of surgical operation. The volumes of 220 mL and 250 mL PG were applied on two patients respectively, to clot bleeding and decrease the mediastinal and pericardial drainage days after operation. The drainage tubes were pulled out on the 4th day after operation. The patients were transferred from ICU to a cardiothoracic surgery ward on the 4th and 5th day respectively. This study suggests that allogeneic platelet concentrate, as a source of PRP to prepare PG, may be used to promote and help the clotting and wound healing on surgical operation.

     

  • These authors contributed equally to this work.
  • loading
  • [1]
    Stolla M, Kapur R, Semple JW. New emerging developments of platelets in transfusion medicine[J]. Transfus Med Rev, 2020, 34(4): 207−208. doi: 10.1016/j.tmrv.2020.09.009
    [2]
    Rainys D, Cepas A, Dambrauskaite K, et al. Effectiveness of autologous platelet-rich plasma gel in the treatment of hard-to-heal leg ulcers: a randomised control trial[J]. J Prescrib Pract, 2020, 2(S8): 32−42. doi: 10.12968/jprp.2020.2.Sup8.32
    [3]
    Chicharro-Alcántara D, Rubio-Zaragoza M, Damiá-Giménez E, et al. Platelet rich plasma: new insights for cutaneous wound healing management[J]. J Funct Biomater, 2018, 9(1): 10. doi: 10.3390/jfb9010010
    [4]
    Hom DB, Linzie BM, Huang TC. The healing effects of autologous platelet gel on acute human skin wounds[J]. Arch Facial Plast Surg, 2007, 9(3): 174−183. doi: 10.1001/archfaci.9.3.174
    [5]
    Mazzucco L, Medici D, Serra M, et al. The use of autologous platelet gel to treat difficult-to-heal wounds: a pilot study[J]. Transfusion, 2010, 44(7): 1013−1018. doi: 10.1111/j.1537-2995.2004.03366.x
    [6]
    Jo CH, Lee SY, Yoon KS, et al. Allogeneic platelet-rich plasma versus corticosteroid injection for the treatment of rotator cuff disease: a randomized controlled trial[J]. J Bone Joint Surg Am, 2020, 102(24): 2129−2137. doi: 10.2106/JBJS.19.01411
    [7]
    Balbo R, Avonto I, Marenchino D, et al. Platelet gel for the treatment of traumatic loss of finger substance[J]. Blood Transfus, 2010, 8(4): 255−259. doi: 10.2450/2009.0129-09
    [8]
    Scevola S, Nicoletti G, Brenta F, et al. Allogenic platelet gel in the treatment of pressure sores: a pilot study[J]. Int Wound J, 2010, 7(3): 184−190. doi: 10.1111/j.1742-481X.2010.00671.x
    [9]
    Wang ZR, Fan YH, Zhang H, et al. Clinical efficacy of allogeneic blood platelet rich plasma in refractory skin ulcer[J]. J Clin Hematol, 2018, 31(12): 895−897. doi: 10.13201/j.issn.1004-2806-b.2018.12.001
    [10]
    Smrke D, Gubina B, Domanoviç D, et al. Allogeneic platelet gel with autologous cancellous bone graft for the treatment of a large bone defect[J]. Eur Surg Res, 2007, 39(3): 170−174. doi: 10.1159/000100490
    [11]
    Calori GM, Tagliabue L, Gala L, et al. Application of rhBMP-7 and platelet-rich plasma in the treatment of long bone non-unions: a prospective randomised clinical study on 120 patients[J]. Injury, 2008, 39(12): 1391−1402. doi: 10.1016/j.injury.2008.08.011
    [12]
    Tian J, Lei XX, Xuan L, et al. The effects of aging, diabetes mellitus, and antiplatelet drugs on growth factors and anti-aging proteins in platelet-rich plasma[J]. Platelets, 2019, 30(6): 773−792. doi: 10.1080/09537104.2018.1514110
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(5)  / Tables(1)

    Article Metrics

    Article views (19) PDF downloads(2) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return