Volume 3 Issue 2
Dec.  2019
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Julio Granados, Antonio Villa-Romero, Marcos Meneses Mayo, Miriam Santiago Ortíz, María Fernanda García Gutiérrez, Víctor Hugo Tovar Méndez, Daniela Ruiz Gómez, Susana Maricela Hernández Doo, Citlaly López Orozco, Adriana Aguirre Telio. The role of free immunoglobulin light chains in serum from SLE patients with or without renal involvement[J]. Blood&Genomics, 2019, 3(2): 139-144. doi: 10.46701/APJBG.2019022019121
Citation: Julio Granados, Antonio Villa-Romero, Marcos Meneses Mayo, Miriam Santiago Ortíz, María Fernanda García Gutiérrez, Víctor Hugo Tovar Méndez, Daniela Ruiz Gómez, Susana Maricela Hernández Doo, Citlaly López Orozco, Adriana Aguirre Telio. The role of free immunoglobulin light chains in serum from SLE patients with or without renal involvement[J]. Blood&Genomics, 2019, 3(2): 139-144. doi: 10.46701/APJBG.2019022019121

The role of free immunoglobulin light chains in serum from SLE patients with or without renal involvement

doi: 10.46701/APJBG.2019022019121
  • Publish Date: 2019-12-30
  • Systemic lupus erythematosus (SLE) is a systemic autoimmune disease. Lupus nephritis (LN) affects 30% to 60% of adult Mexican patients. This study aimed to determine whether immunoglobulin free light chains (FLCs) constitute a biological marker for LN. FLCs have been previously studied as disease activity biomarkers, but patients with kidney damage are frequently excluded. A total of 75 consecutive SLE patients were recruited from a third-level hospital in Mexico City. Thirty-eight patients were diagnosed with LN, and the remaining 37 patients without kidney failure were included as a control group. FLCs concentration was measured by nephelometry. The results showed that SLE patients with high FLCs concentration had a higher rate of kidney failure and that the probability of renal failure increased by 2.4% for each mg/dL of κ FLCs, and 1.7% for each mg/dL of λ FLCs. This study suggests that high FLCs concentration is associated with LN, and therefore may be considered as a possible biomarker for SLE activity.

     

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