Volume 2 Issue 3
Sep.  2018
Turn off MathJax
Article Contents
Xuan Gu, Qi Tang. Tumor immune microenvironment: sanctuary of tumor and target for immunotherapy[J]. Blood&Genomics, 2018, 2(3): 141-148. doi: 10.46701/APJBG.2018032018125
Citation: Xuan Gu, Qi Tang. Tumor immune microenvironment: sanctuary of tumor and target for immunotherapy[J]. Blood&Genomics, 2018, 2(3): 141-148. doi: 10.46701/APJBG.2018032018125

Tumor immune microenvironment: sanctuary of tumor and target for immunotherapy

doi: 10.46701/APJBG.2018032018125
  • Available Online: 2021-06-30
  • Publish Date: 2018-09-30
  • The tumor immune microenvironment (TIME) is the cellular environment in which tumors exist. This includes: surrounding blood vessels, immune cells, fibroblasts, bone marrow-derived inflammatory cells, lymphocytes, signaling molecules, immune checkpoint proteins and the extracellular matrix (ECM). The TIME plays a critical role in cancer progression and regulation. Tumors can influence the microenvironment by releasing extracellular signals, promoting tumor angiogenesis and inducing peripheral immune tolerance, while the immune cells in the microenvironment can affect the growth and evolution of cancerous cells. The molecules and cells in the TIME influence disease outcome by altering the balance of suppressive versus cytotoxic responses in the vicinity of the tumor. Having a better understanding of the tumor immune microenvironment will pave the way for identifying new targets for immunotherapies that promote cancer elimination.

     

  • loading
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (1193) PDF downloads(894) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return