Volume 1 Issue 2
Jun.  2017
Turn off MathJax
Article Contents
Xiaohua Tu, Yan Zang, Haihui Gu, Huijun Guo, Xin Ye, Zhanshan Cha, Baohua Qian. Perioperative blood transfusion is associated with poorer survival in patients with gastric cancer[J]. Blood&Genomics, 2017, 1(2): 7-13. doi: 10.46701/APJBG.20170217024
Citation: Xiaohua Tu, Yan Zang, Haihui Gu, Huijun Guo, Xin Ye, Zhanshan Cha, Baohua Qian. Perioperative blood transfusion is associated with poorer survival in patients with gastric cancer[J]. Blood&Genomics, 2017, 1(2): 7-13. doi: 10.46701/APJBG.20170217024

Perioperative blood transfusion is associated with poorer survival in patients with gastric cancer

doi: 10.46701/APJBG.20170217024
  • Publish Date: 2017-06-30
  • The putative prognostic significance of perioperative blood transfusions on gastric cancers is controversial and the published results are contradictory. The aim of this study was to evaluate the prognostic influence of transfusion on Chinese gastric cancer surgery. Six hundreds and seventy-six patients who underwent curative gastrectomy for gastric cancer from 2000 to 2004 were retrospectively reviewed. Uni- and multivariate analyses of the incidence and amount of transfusion, and a comparison of the clinicopathological features were performed. Subgroup analyses of prognosis according to stage, tumor size, and pretreatment anemia were carried out. Blood transfusion was significantly associated with older age (>60 year), larger tumor (>6 cm), upper and middle location, surgical margin status, and pretreatment anemia. In addition, tumors in the transfused group were more advanced in depth of invasion, nodal stage, and TNM stage. No significant relationship was found between the amount of transfused blood and prognosis. Subgroup analyses of prognosis according to stage showed significant differences in stages II and III, between the transfused and nontransfused groups. Significant difference between the transfused and nontransfused groups could be observed in two subgroups of tumor size. Patients with or without anemia in the nontransfused group both had a longer survival time than those in the transfused group. On multivariate analysis, transfusion was shown to be an independent risk factor for poor prognosis. This study suggests that perioperative blood transfusion is associated with a significantly worse prognosis following gastric cancer surgery. The parameters such as advanced stage, tumor size, and anemia do not affect its prognostic value.

     

  • loading
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (1537) PDF downloads(1331) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return