Volume 1 Issue 1
Mar.  2017
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Pu Xu, Yan Li, Su Zhou, Ziqi He, You Yang, Hua Yu. Human RBC alloimmunization evaluation after exposure to foreign E antigen of the rhesus system in transfusion[J]. Blood&Genomics, 2017, 1(1): 37-42. doi: 10.46701/APJBG.20170116009
Citation: Pu Xu, Yan Li, Su Zhou, Ziqi He, You Yang, Hua Yu. Human RBC alloimmunization evaluation after exposure to foreign E antigen of the rhesus system in transfusion[J]. Blood&Genomics, 2017, 1(1): 37-42. doi: 10.46701/APJBG.20170116009

Human RBC alloimmunization evaluation after exposure to foreign E antigen of the rhesus system in transfusion

doi: 10.46701/APJBG.20170116009
  • Publish Date: 2017-03-30
  • Anti-E alloantibody has been one of the most frequently detected clinically significant alloantibodies in previous studies. Red blood cell (RBC) transfusion is unique in its common intravenous introduction of foreign E antigen and provides a valuable opportunity to study the human immunologic response to intravenous foreign E antigen. Patients exposed to foreign E antigen while receiving RBC transfusions are at risk of forming anti-E alloantibody. Valid estimates of anti-E alloimmunization risk are clinically important, but the forming mechanism of anti-E alloimmunization remains unclear. Here, we screened 516 inpatients at risk of exposure to foreign E antigen while receiving RBC transfusions and monitored the development of anti-E alloantibody for up to two years after left hospital. However, only 2 cases of anti-E alloimmunization were identified in this study. Patients who received RBC transfusion had a very high risk of exposure to foreign E antigen, but the anti-E alloantibody production incidence was very low and few anti-E alloantibodies were produced within 3 to 6 months after RBC transfusion in this study. Further research would contribute to our knowledge of the anti-E alloimmunization mechanism and prevent anti-E development, which would be significantly useful in clinical for transfusions, obstetric management, and the evaluation and management of transfusion reactions in laboratory and institutional resources and cost reduction in healthcare system.

     

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