Volume 5 Issue 2
Dec.  2021
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Yan Peng, Zhenqing Feng. The progress and perspectives of CAR-T cell therapy[J]. Blood&Genomics, 2021, 5(2): 107-111. doi: 10.46701/BG.2021022021126
Citation: Yan Peng, Zhenqing Feng. The progress and perspectives of CAR-T cell therapy[J]. Blood&Genomics, 2021, 5(2): 107-111. doi: 10.46701/BG.2021022021126

The progress and perspectives of CAR-T cell therapy

doi: 10.46701/BG.2021022021126
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  • Corresponding author: Zhenqing Feng, National Health Commission Key Lab. of Antibody Techniques, Nanjing Medical University, Nanjing, Jiangsu 211166, China. E-mail: fengzhenqing@njmu.edu.cn
  • Received Date: 2021-09-26
  • Accepted Date: 2021-11-19
  • Rev Recd Date: 2021-11-16
  • Available Online: 2022-01-06
  • Publish Date: 2021-12-31
  • CAR-T cell therapy has already achieved world-renowned clinical effects in the treatment of hematological malignancies. Due to the tumor heterogeneity, immunosuppressive microenvironment, and other factors, CAR-T cell therapy has still not shown obvious clinical efficacy in clinical treatment of solid tumors. However, great progress has been made in the preparation of CAR-T cells in recent years, including T cells redirected for universal cytokine mediated killing, universal CAR -T cells, non-viral vector CAR-T cells, SynNotch technology, SUPRA CAR technology, regulated CAR-T cells, and bi-specific CAR-T cells, etc. Future research and development of CAR-T cell therapy will be focused on these following aspects: the combined application of CAR-T cells with different targets, known as "Cocktail CAR-T cells", is expected to increase efficiency toward solid tumors; based on systemic biology/synthetic biology theories, CAR-T cells are likely to be transformed to robot or intelligent system by introducing sensors, logic gates, and logic circuits. This article mainly comments on research progress and perspectives on CAR-T cell therapy in solid tumor treatment.

     

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