Volume 5 Issue 1
Jun.  2021
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Zhiruo Song, Yufeng Zhang, Yuanjie Zhu, Mingming Zhang, Xinjian Liu, Minjun Ji. Screening of tumor-targeting peptides for diagnosis and therapy through phage display technology[J]. Blood&Genomics, 2021, 5(1): 13-20. doi: 10.46701/BG.2021012021103
Citation: Zhiruo Song, Yufeng Zhang, Yuanjie Zhu, Mingming Zhang, Xinjian Liu, Minjun Ji. Screening of tumor-targeting peptides for diagnosis and therapy through phage display technology[J]. Blood&Genomics, 2021, 5(1): 13-20. doi: 10.46701/BG.2021012021103

Screening of tumor-targeting peptides for diagnosis and therapy through phage display technology

doi: 10.46701/BG.2021012021103
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  • Corresponding author: Xinjian Liu, Department of Pathogen Biology, Nanjing Medical University, 101 Longmian Avenue, Nanjing, Jiangsu 211166, China. E-mail: liuxinjian@njmu.edu.cn
  • Received Date: 2021-02-02
  • Accepted Date: 2021-04-15
  • Rev Recd Date: 2021-03-24
  • Publish Date: 2021-06-01
  • Phage display technology was introduced by G. Smith in 1985, which is highly effective in the selection of affinity peptides from a library containing billions of display peptides. The obtained peptides show potential efficacy in the development of further clinical applications, especially in tumor treatment. In this review, the basic principles, limits, developments of phage display technology and peptide libraries are introduced. Following that, the amino acid sequence of tumor target peptides for hematological and other systems are discussed. Finally, the application of target peptides in the design of imaging probes and the development of target peptide drugs for diagnosis and therapy are noted.


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