Volume 2 Issue 1
Mar.  2018
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Dongmei Wang, Xiaoyan Shan, Lijun Wang, Wei Li, Na Liu, Dongmei Li, Yuanyuan Jing, Yanjun Jia. The incidence and clinical relevance of anti-HLA and/or MICA antibodies in patients with long-term survival renal allo-grafts[J]. Blood&Genomics, 2018, 2(1): 45-51. doi: 10.46701/APJBG.2018012017065
Citation: Dongmei Wang, Xiaoyan Shan, Lijun Wang, Wei Li, Na Liu, Dongmei Li, Yuanyuan Jing, Yanjun Jia. The incidence and clinical relevance of anti-HLA and/or MICA antibodies in patients with long-term survival renal allo-grafts[J]. Blood&Genomics, 2018, 2(1): 45-51. doi: 10.46701/APJBG.2018012017065

The incidence and clinical relevance of anti-HLA and/or MICA antibodies in patients with long-term survival renal allo-grafts

doi: 10.46701/APJBG.2018012017065
  • Publish Date: 2018-03-30
  • The purpose of this study was to analyze the incidence and clinical relevance of anti-HLA and/or MICA antibodies in renal allo-grafts transplant recipients with long-term renal survival (> 5 years). This retrospective study collected post-transplant serum samples from a total of 110 patients which were used to detect the incidence of anti-HLA and/or MICA antibodies as well as anti-HLA donor specific antibodies. Among these 110 patients, 72 patients had antibodies against HLA and/or MICA at the time of test, 61 had only anti-HLA antibodies, 31 had anti-MICA antibodies, and 38 were antibody negative. There was no difference in the number of patients developing antibodies against non-donor specific antibodies, donor specific antibodies, Class I donor specific antibodies, Class II donor specific antibodies or MICA antibodies between normal function group (serum creatinine level < 2.0 mg/dL) and dysfunction group (serum creatinine level > 2.0 mg/dL). For the serum creatinine level, estimated glomerular filtration rate and blood urea nitrogen level, patients with different antibodies were not statistically different to antibody-negative patients. Cox regression analysis showed that the type of transplantation and HLA mismatch number were significant negative risk factors for the development of anti-HLA (P < 0.05). Our results suggested that the anti-HLA antibody status has little impact on the renal graft function in the long-term survival allo-graft renal recipients.

     

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