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Ting Lu, Chunyan Gu. AURKA is a potential target for multiple myeloma therapy[J]. Blood&Genomics, 2017, 1(3): 47-51. doi: 10.46701/APJBG.2017032017021
Citation: Ting Lu, Chunyan Gu. AURKA is a potential target for multiple myeloma therapy[J]. Blood&Genomics, 2017, 1(3): 47-51. doi: 10.46701/APJBG.2017032017021

AURKA is a potential target for multiple myeloma therapy

doi: 10.46701/APJBG.2017032017021
  • Publish Date: 2017-09-30
  • Multiple myeloma (MM) is an incurable disease with the second most frequent hematopoietic malignancy. In this study, we found that the expression of Aurora kinase A (AURKA) was significantly increased in patients with high-risk multiple myeloma, especially in proliferation subgroups. MLN8237, a small molecule AURKA inhibitor, inhibited MM cell proliferation by inducing cell apoptosis and injury. Thus, we speculate MLN8237 is a potential therapeutic agent for MM and AURKA may be a potential target for MM treatment.

     

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